Enantiomers in arthritic disorders
Identifieur interne : 003035 ( Main/Exploration ); précédent : 003034; suivant : 003036Enantiomers in arthritic disorders
Auteurs : Kenneth M. Williams [Australie]Source :
- Pharmacology and Therapeutics [ 0163-7258 ] ; 1990.
English descriptors
- Teeft :
- Absolute configuration, Adverse effects, Amino acids, Analog, Antiinflammatory, Antimalarial, Antirheumatic, Antirheumatic drugs, Arthritic, Arthritic disorders, Arthritis, Asymmetric, Aurothiomalate, Benoxaprofen, Biochem, Biological activity, Chem, Chiral, Chiral inversion, Chloroquine, Clin, Clinical pharmacology, Collagen synthesis, Cooh, Copyright holder, Cyclooxygenase, Cyclophosphamide, Cytotoxic, Dextramisole, Dispos, Dos, Drug metab, Enantiomer, Enantiomeric, Enantioselective, Enantioselective disposition, Enantioselectivity, Etodolac, Excretion, Fenoprofen, Flurbiprofen, Furst, Gastric, Glucuronides, Greater toxicity, Hydroxychloroquine, Ibuprofen, Ibuprofen enantiomers, Inversion, Isomer, Jamali, Ketoprofen, Levamisole, Lipid, Meffin, Metab, Metabolic chiral inversion, Metabolism, Methotrexate, Microsome, Monooxygenase, Munthe, Naproxen, Nonsteroidal, Optical isomers, Oral administration, Oxyphenbutazone, Pathway, Penicillamine, Perfused, Pharm, Pharmac, Pharmacokinetic, Pharmacokinetics, Phenylbutazone, Plasma concentrations, Primaquine, Prostaglandin, Prostaglandin synthesis, Prostaglandin synthetase, Pyridoxine, Racemate, Racemates, Racemic, Racemic drug, Renal, Renal function, Rheum, Rheumatic, Rheumatic disease, Rheumatic diseases, Rheumatoid, Rheumatoid arthritis, Rheumatol, Rudge, Shen, Stereoselective, Sulfide, Sulindac, Suppl, Synthetase, Tetramisole, Thalidomide, Thioester, Thioesters, Thiol, Thiomalate, Tiaprofenic acid, Toxicity, Urine.
Abstract
Abstract: Drugs which have a center of asymmetry are often administered as an equal mixture of the two possible enantiomeric forms i.e. a racemete. However, there are frequently large pharmacodynamic and pharmacokinetic differences between enantiomers. Consequently, it is possible that while one enantiomer mediates the antiinflammatory or antirheumatic action, the other enantiomer, although adding little to the efficacy of the drug, may contribute to its adverse effects. Asymmetric drugs may also serve as sensitive pharmacological probes of the mechanisns underlying the action of drugs and the inflammatory processes which they modulate. These concepts are the focus for this review.
Url:
DOI: 10.1016/0163-7258(90)90095-J
Affiliations:
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However, there are frequently large pharmacodynamic and pharmacokinetic differences between enantiomers. Consequently, it is possible that while one enantiomer mediates the antiinflammatory or antirheumatic action, the other enantiomer, although adding little to the efficacy of the drug, may contribute to its adverse effects. Asymmetric drugs may also serve as sensitive pharmacological probes of the mechanisns underlying the action of drugs and the inflammatory processes which they modulate. These concepts are the focus for this review.</div></front></TEI><affiliations><list><country><li>Australie</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Williams, Kenneth M" sort="Williams, Kenneth M" uniqKey="Williams K" first="Kenneth M." last="Williams">Kenneth M. Williams</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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